Protein networks in disease
Our program takes advantage of properties of protein networks in cancer to understand, diagnose and treat diseases, such as cancer and neurodegenerative diseases.
It aims to investigate the identity and the architecture of protein networks in cells exposed to chronic molecular and environmental stresses with the goal of understanding disease mechanisms and identifying vulnerabilities.
It aims to take advantage of these vulnerabilities to discover and develop drug candidates, biomarkers, diagnostics and treatment strategies.
Our ultimate goal is the translation of our discoveries from bench to bedside.
Publications:
Featured in:
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Kai Bartkowiak & Klaus Pantel. Cancer: A shocking protein complex. Nature (2016), News&Views, doi:10.1038/nature19476
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Stu Borman. Heat-shock protein complexes serve as cancer drug targets. ‘Epichaperomes’ that form in some cancer cells might enable selective therapies. CE&N News, Volume 94 Issue 40, pp. 10-11 Science & Technology Concentrates; October 10, 2016
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Andrew P. Han. Assays for Heat Shock Protein Complexes Could Serve as Companion Dx for Inhibitor Drugs. GenomeWeb, Proteomics & Protein Research Oct 10, 2016
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Anna Dart. Networking: a survival guide. Nature Reviews Cancer | Published online 11 Nov 2016; doi:10.1038/nrc.2016.125
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Heidi A. Dahlmann. Chaperome Complexes Influence Tumor Survival. ACS Chem. Biol., 2016, 11 (11), pp 2941–2943. DOI: 10.1021/acschembio.6b00969
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Philipp Markolin. How a complex network of proteins contributes to cancer survival. https://medium.com/advances-in-biological-science/how-a-complex-network…
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https://www.mskcc.org/blog/experimental-cancer-drug-developed-msk-leads…
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https://www.prnewswire.com/news-releases/samus-therapeutics-announces-l…