Protein networks in disease
Our program takes advantage of properties of protein networks in cancer to understand, diagnose and treat diseases, such as cancer and neurodegenerative diseases.
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It aims to investigate the identity and the architecture of protein networks in cells exposed to chronic molecular and environmental stresses with the goal of understanding disease mechanisms and identifying vulnerabilities.
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It aims to take advantage of these vulnerabilities to discover and develop drug candidates, biomarkers, diagnostics and treatment strategies.
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Our ultimate goal is the translation of our discoveries from bench to bedside.


Publications:
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Featured in:
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Kai Bartkowiak & Klaus Pantel. Cancer: A shocking protein complex. Nature (2016), News&Views, doi:10.1038/nature19476
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Stu Borman. Heat-shock protein complexes serve as cancer drug targets. ‘Epichaperomes’ that form in some cancer cells might enable selective therapies. CE&N News, Volume 94 Issue 40, pp. 10-11 Science & Technology Concentrates; October 10, 2016
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Andrew P. Han. Assays for Heat Shock Protein Complexes Could Serve as Companion Dx for Inhibitor Drugs. GenomeWeb, Proteomics & Protein Research Oct 10, 2016
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Anna Dart. Networking: a survival guide. Nature Reviews Cancer | Published online 11 Nov 2016; doi:10.1038/nrc.2016.125
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Heidi A. Dahlmann. Chaperome Complexes Influence Tumor Survival. ACS Chem. Biol., 2016, 11 (11), pp 2941–2943. DOI: 10.1021/acschembio.6b00969
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Philipp Markolin. How a complex network of proteins contributes to cancer survival. https://medium.com/advances-in-biological-science/how-a-complex-network…
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https://www.mskcc.org/blog/experimental-cancer-drug-developed-msk-leads…
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https://www.prnewswire.com/news-releases/samus-therapeutics-announces-l…