Chaperome in neurodegnerative diseases

Chiosis G. 2018 NIH Alzheimer’s Research Summit: Path to Treatment and Prevention. NIH campus, Bethesda, Maryland, March 1-2, 2018. #ADSummit18

Publications:

Kishinevsky S, Wang T, Rodina A, Chung SY, Xu C, Philip J, Taldone T, Joshi S, Alpaugh ML, Bolaender A, Gutbier S, Sandhu D, Fattahi F, Zimmer B, Shah SK, Chang E, Inda C, Koren J 3rd, Saurat NG, Leist M, Gross SS, Seshan VE, Klein C, Tomishima MJ, Erdjument-Bromage H, Neubert TA, Henrickson RC, Chiosis G*, Studer L*. HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons. Nat Commun. 2018 Oct 19;9(1):4345. doi: 10.1038/s41467-018-06486-6.
Regulatory Chaperone Complexes in Neurodegenerative Diseases: a Perspective on Therapeutic Intervention. Carman A, Kishinevsky S, Koren J, Lou W, Chiosis G. Curr Alzheimer Res. 2013 Nov 19.
Heat shock protein 90: translation from cancer to Alzheimer’s disease treatment?Luo W, Rodina A, Chiosis G. BMC Neurosci. 2008 Dec 3;9 Suppl 2:S7.
The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.Wang L, Xie C, Greggio E, Parisiadou L, Shim H, Sun L, Chandran J, Lin X, Lai C, Yang WJ, Moore DJ, Dawson TM, Dawson VL, Chiosis G, Cookson MR, Cai H. J Neurosci. 2008 Mar 26;28(13):3384-91.
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, Moulick K, Aguirre J, Wu N, Greengard P, Chiosis G. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9511-6.