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A unique chemical biology approach to understand, diagnose, and treat cellular processes associated with chronic molecular stress, with the ultimate goal of developing novel therapeutic options for use in the clinic.
Targeting stressor-induced dysfunctions in protein–protein interaction networks via epichaperomes

Read about our opinion on targeting dysfunctions in protein-protein interactions via epichaperomes and implications of epichaperome therapy via a precision medicine approach. 

Synthesis of 124I-labeled epichaperome probes and assessment in visualizing pathologic protein-protein interaction networks in tumor bearing mice

Check out our detailed protocol on the synthesis of epichaperome targeting clinical agents, [124I]-PU-H71 and [124I]-PU-AD and specific steps in the use of these reagents to visualize pathologic PPI networks. 

Epichaperomes as a Gateway to Understanding, Diagnosing, and Treating Disease Through Rebalancing Protein–Protein Interaction Networks

This book chapter highlights several chemical probes, from epichaperome disrupters to epichaperome affinity-purification tools and epichaperome detection and quantitation probes, and the use of these probes as therapeutic strategies aimed at normalizing PPI networks, especially in cancer and neurodegenerative diseases. 

How Aberrant N-Glycosylation Can Alter Protein Functionality and Ligand Binding: an Atomistic View

Our collaborator, the colombo team, integrated computational and experimental tools to unveil the role of N-glycosylation of specific residues in glucose-regulated protein 94 (GRP94) to modulates its internal dynamics and shed light on the determinants of GRP94 response to ligands. 

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Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer

We used an innovative and unbiased epichaperomic platform to show how epichaperome targeting probes makes the cancer cells maxed-out their capacity to remodel PPI networks and how the cells respond in the presence of additional therapeutic stress at this state. Check out our feature on EinPressWire:

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Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia
Disease-specific interactome alterations via epichaperomics: the case for Alzheimer’s disease
The penalty of stress - Epichaperomes negatively reshaping the brain in neurodegenerative disorders
News: Study Reveals a New Way That Stress and Aging Lead to Alzheimer’s

Researchers find that a targeted approach being developed to treat certain cancers also appears to help rewire brain circuitry in Alzheimer’s disease.

News: Bull’s-Eye: Imaging Technology Could Confirm When a Drug Is Going to the Right Place

By combining an imaging agent with a targeted therapy, MSK researchers can determine which tumors are likely to respond to the drug and then confirm that the drug is reaching the tumor.

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Our latest article was featured on the cover of the journal of Cancer Cell

Pillarsetty N, Jhaveri K, Taldone T, et al. Paradigms for Precision Medicine in Epichaperome Cancer Therapy. Cancer Cell. 2019;36(5):559–573.e7. doi:10.1016/j.ccell.2019.09.007

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