Synthesis of 124I-labeled epichaperome probes and assessment in visualizing pathologic protein-protein interaction networks in tumor bearing mice
Check out our detailed protocol on the synthesis of epichaperome targeting clinical agents, [124I]-PU-H71 and [124I]-PU-AD and specific steps in the use of these reagents to visualize pathologic PPI networks.
Epichaperomes as a Gateway to Understanding, Diagnosing, and Treating Disease Through Rebalancing Protein–Protein Interaction Networks
This book chapter highlights several chemical probes, from epichaperome disrupters to epichaperome affinity-purification tools and epichaperome detection and quantitation probes, and the use of these probes as therapeutic strategies aimed at normalizing PPI networks, especially in cancer and neurodegenerative diseases.
How Aberrant N-Glycosylation Can Alter Protein Functionality and Ligand Binding: an Atomistic View
Our collaborator, the colombo team, integrated computational and experimental tools to unveil the role of N-glycosylation of specific residues in glucose-regulated protein 94 (GRP94) to modulates its internal dynamics and shed light on the determinants of GRP94 response to ligands.
Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
We used an innovative and unbiased epichaperomic platform to show how epichaperome targeting probes makes the cancer cells maxed-out their capacity to remodel PPI networks and how the cells respond in the presence of additional therapeutic stress at this state. Check out our feature on EinPressWire: https://www.einpresswire.com/article/557136874/a-cellular-traffic-jam-for-precision-medicine-in-cancer
Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia
Check out our feature on the Weill Cornell Medicine website: https://news.weill.cornell.edu/news/2021/09/it%E2%80%99s-an-absolute-miracle-battling-a-deadly-blood-cancer-a-new-jersey-woman-gets-a